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Neuronal Intrinsic Signaling for Neuroprotection and Axon Regeneration

Lecture

Date and Time

December 8, 2017 11:30 AM - 1:15 PM

Availability

RSVP Required.

Location

Stanford Center at Peking University
Langrun Yuan, Peking University

Summary

 

Axonopathy is a typical early characteristic of neurodegenerative diseases in central nervous system (CNS),

which leads to axon degeneration and retrograde neuronal cell death. It is critical to decipher the upstream

signals that trigger the neurodegeneration cascade to minimize the severe consequences of progressive CNS

dysfunction. It is also upmost interest to promote CNS axon regeneration for neural repair. Optic neuropathies

are a group of retinal ganglion cell (RGC) diseases with features of axonopathy: they are initiated by optic

nerve (ON) injury and that produces secondary RGC death. Prof. Hu’s study of three in vivo mouse models of

optic neuropathies (traumatic optic nerve injury, glaucoma and EAE/optic neuritis) revealed that both acute

traumatic injury and chronic insult of ON induce endoplasmic reticulum (ER) stress and activate the unfolded

protein response (UPR) signal transduction pathways in RGCs. Modulation of two key downstream pathways

of ER stress synergistically promote survival of both RGC somata and axons in all three optic neuropathy

models, suggest that neuronal ER stress is a general upstream mechanism for both events in CNS

axonopathies, and that axon injury-induced ER stress is the link between the sequential events of axon injury

and neuronal soma death. Using the same model, we also revealed a complex neuron-intrinsic balancing

mechanism involving AKT as the nodal point of PI3K, mTORC1/2 and GSK3β that coordinates both positive

and negative cues to regulate adult CNS axon regeneration

 

Speaker - Professor Hu Yang

 

Prof. Hu, Assistant Professor of Ophthalmology at Stanford

University School of Medicine, is also member of Bio-X

and of Stanford Neurosciences Institute. He received the

Doughlas Johnson Award for Glaucoma Research (2013)

and the Knight Templar Eye Foundation Travel Fellowship

Award (2016). Prof. Hu received his Ph.D in Neuroscience

at Weill Medical College of Cornell University and MD from

Beijing Medical University.

 

 

 

Registration

 

Lunch box option provided

 

 

Coming to SCPKU

 

The nearest Peking University entrance to the Center is

the Northeast Gate on Zhongguancun Beidajie. Please

make sure to bring your ID or passport for registration at

the gate. We will send you a reminder and map of the

Center once you have successfully registered. For

inquiries, please call (86) 10 62744170.

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